Brain IRS2 Signaling Coordinates Life Span and Nutrient Homeostasis
نویسندگان
چکیده
منابع مشابه
Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis".
Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
متن کاملNutrient Homeostasis Brain IRS 2 Signaling Coordinates Life Span
http://www.sciencemag.org/cgi/content/full/317/5836/369 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/317/5836/369/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...
متن کاملIrs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth.
Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF receptor signals with heterologous pathways to coordinate growth and metabolism. Since Irs2 is thought to be especially important in hepatic nutrient homeostasis, we deleted Irs2 [corrected] from hepatocytes of WT mice (called LKO) or genetically insulin-resistant Irs1-/- mice (called LKO::Irs1-/-). Viable LKO::Irs1...
متن کاملBrain oscillatory complexity across the life span.
OBJECTIVE Considering the increasing use of complexity estimates in neuropsychiatric populations, a normative study is critical to define the 'normal' behaviour of brain oscillatory complexity across the life span. METHOD This study examines changes in resting-state magnetoencephalogram (MEG) complexity - quantified with the Lempel-Ziv complexity (LZC) algorithm - due to age and gender in a l...
متن کاملBrain weight and life-span in primate species.
In haplorhine primates (tarsiers, monkeys, apes, and humans), there is a significant correlation between brain weight and maximum life-span when the effect of body size is removed. There is also a significant correlation in haplorhine primates between brain weight and female age at first reproduction. For strepsirhine primates (lorises and lemurs), there are no significant correlations between ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2007
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1142179